let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma
نویسندگان
چکیده
منابع مشابه
let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma
BACKGROUND Renal cell carcinoma (RCC) is characterized by inherent resistance to chemotherapy. Earlier studies demonstrated that microRNAs (miRNAs) might be involved in the chemosensitivity of cancers. MicroRNA let-7, a putative tumor suppressor, is dysregulated in many cancers. Our study aims to investigate the exact role of let-7 in chemotherapy sensitivity of 5-fluorouracil (5-FU) in RCC. ...
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OBJECTIVE The aim of the present study was to explore mechanisms by which let-7c suppresses NSCLC cell proliferation. METHODS The expression level of let-7c was quantified by qRT-PCR. A549 and H1299 cells were transfected with let-7c mimics to restore the expression of let-7c. The effects of let-7c were then assessed by cell proliferation, colony formation and cell cycle assay. Mouse experime...
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ژورنال
عنوان ژورنال: World Journal of Surgical Oncology
سال: 2015
ISSN: 1477-7819
DOI: 10.1186/s12957-015-0596-4